| ACUTE Trial Summaries | |
| FASTEST | rFVIIa for acute hemorrhagic stroke | ID-IMR | Observational imaging study, CTP post EVT with TICI 2c/3 |
| SISTER | Novel lytic for patients not elgible for acute treatment |
| STEP DOMAIN A (Low NIHSS) | EVT expansion for LVO patients with low stroke scale |
FASTEST
rFVIIa for acute hemorrhagic stroke
FASTEST: ABC/2 ICH Volume Calculator
FASTEST— (PI: Walsh)
LKW
2 hrs
Pre-stroke mRS
N/A (18-80)
Other:
Positive spot sign on CTA, EFIC initial consenting allowed
Sites:
UCMC
ORDERS:
N/A - kit in SRU Omnicell
Clinical Trials ID:
Contact:
Randomization Hotline:
ID-IMR
Observational imaging study, CTP post EVT with TICI 2c/3
ID-IMR— (PI: Aziz)
LVO Required
ICA/M1/M2 (any)
LKW
24 hrs
Pre-stroke mRS
—
NIHSS
—
ASPECTS
—
MRI Capability
Must be able to undergo MRI
ICT/AC
—
MT Required
Yes
MT Device
—
Final mTICI
2c-3
Sites:
UCMC and Jewish
ORDERS:
In Comments area of stat CTP order, please write: "RESEARCH, NO READ, Aziz-2024-0526-ID IMR, perform imaging according to clinical standard for patient's disease, perform by 90 minutes of qualifying reperfusion score. Technologist, please pend read to Karen Putnick"
Clinical Trials ID:
Contact:
SISTER
Novel lytic for patients not elgible for acute treatment
SISTER — (Stite PI: Aziz)
LVO Required
- LVO not required
- Anterior circ perfusion mismatch
LKW
4.5 – 24 hrs
Pre-stroke mRS
0 - 2
NIHSS
≥4
ASPECTS
>6 (>7 if MRI)
MRI Capability
—
ICT/AC
No Thrombolytics (IV/IA)
MT Required
No
MT Device
—
Final mTICI
—
Sites:
UCMC
ORDERS:
—
Clinical Trials ID:
Contact:
Yasmin (412-913-8424)
Randomization Hotline:
STEP DOMAIN A (Low NIHSS)
EVT expansion for LVO patients with low stroke scale
STEP-Domain A (Low NIHSS) — (PI: Demel)
LVO Required
ICA or M1 MCA
LKW
24 hrs
Pre-stroke mRS
0-2
NIHSS
0-5
ASPECTS
>6 (>7 if MRI)
MRI Capability
—
ICT/AC
—
MT Required
—
MT Device
—
Final mTICI
—
Sites:
UCMC
ORDERS:
—
Clinical Trials ID:
Contact:
Randomization Hotline: