ACUTE Trial Summaries
FASTEST rFVIIa for acute hemorrhagic stroke
SISTER Novel lytic for patients not elgible for acute treatment
STEP DOMAIN A (Low NIHSS) EVT expansion for LVO patients with low stroke scale
STEP DOMAIN A (MVO/DMVO) EVT expansion for MeVO patients
FASTEST

rFVIIa for acute hemorrhagic stroke

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FASTEST— (PI: Walsh)
LKW
2 hrs
Pre-stroke mRS
N/A (18-80)
Other:
Positive spot sign on CTA, EFIC initial consenting allowed
Sites:
UCMC
ORDERS:
N/A - kit in SRU Omnicell
Clinical Trials ID:
NCT03496883
Contact:
Stephanie Thomas: 513-315-4001 (lead coordinator)
Kyle Walsh: 989-996-0417 (site PI)
Randomization Hotline:
843-805-5301
SISTER

Novel lytic for patients not elgible for acute treatment

SISTER — (Stite PI: Aziz)
LVO Required
  1. LVO not required
  2. Anterior circ perfusion mismatch
LKW
4.5 – 24 hrs
Pre-stroke mRS
0 - 2
NIHSS
≥4
ASPECTS
≥6 (≥7 if MRI)
MRI Capability
—
EVT/Anticogulation
No Thrombolytics (IV/IA)
Thrombectomy Required
No
Thrombectomy Device
—
Final mTICI
—
Sites:
UCMC
ORDERS:
—
Clinical Trials ID:
NCT05948566
Contact:
Emma King (513-805-2295)
SISTER Hotline:
866-212-7187
STEP DOMAIN A (Low NIHSS)

EVT expansion for LVO patients with low stroke scale

STEP-Domain A (Low NIHSS) — (Site PIs: Shirani and Demel)
LVO Required
ICA or M1 MCA
LKW
24 hrs
Pre-stroke mRS
0-2
NIHSS
0-5
ASPECTS
≥6 (≥7 if MRI)
MRI Capability
—
EVT/Anticogulation
—
Thrombectomy Required
—
Thrombectomy Device
—
Final mTICI
—
Sites:
UCMC
ORDERS:
—
Clinical Trials ID:
NCT06289985
Contacts:
Emma King - Lead coordinator: (513-805-2295)
Stacie Demel - Site PI: (570-220-5528)
Peyman Shirani - Site PI: (832-525-1427)
STEP Hotline:
833-477-7837
STEP DOMAIN A (MVO/DMVO)

EVT expansion for MeVO/DMVO patients

STEP-Domain A (Low NIHSS) — (Site PIs: Shirani and Demel)
LVO Required
Non-dom/Co-dom M2 or M3
LKW
24 hrs
Pre-stroke mRS
0-2
NIHSS
≥8
ASPECTS
≥6 (≥7 if MRI)
MRI Capability
—
EVT/Anticogulation
—
Thrombectomy Required
—
Thrombectomy Device
—
Final mTICI
—
Sites:
UCMC
ORDERS:
—
Clinical Trials ID:
NCT06289985
Contacts:
Emma King - Lead coordinator: (513-805-2295)
Stacie Demel - Site PI: (570-220-5528)
Peyman Shirani - Site PI: (832-525-1427)
STEP Hotline:
833-477-7837