Trial criteria One-Liners
ARPEGGIO Aapixaban vs ASA in patients with recent ICH and Afib
ID-IMR Severe ICAD with downstream stroke
SISTER Milvexian for stroke prevention after an AIS or high-risk TIA
STEP DOMAIN A
(Low NIHSS)		 Statin use after spontaneous lobar ICH
ARPEGGIO
ARPEGGIO— (PI: Wechsler)
LVO Required
ICA/M1/M2
LKW
24 hrs
Pre-stroke mRS
0 - 2
NIHSS
≥6
ASPECTS
≥5
MRI Capability
—
ICT/AC
No Pre EVT Thrombolytics.
IA lytics after reperfusion allowed
MT Required
Yes
MT Device
Intent to use FDA approved device
Final mTICI
0-3

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ID-IMR
ID-IMR— (PI: Aziz)
LVO Required
ICA/M1/M2 (any)
LKW
24 hrs
Pre-stroke mRS
—
NIHSS
—
ASPECTS
—
MRI Capability
Must be able to undergo MRI
ICT/AC
—
MT Required
Yes
MT Device
—
Final mTICI
2c-3

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SISTER
SISTER — (Stite PI: Aziz)
LVO Required
  1. LVO not required
  2. Anterior circ perfusion mismatch
LKW
4.5 – 24 hrs
Pre-stroke mRS
0 - 2
NIHSS
≥4
ASPECTS
>6 (>7 if MRI)
MRI Capability
—
ICT/AC
No Thrombolytics (IV/IA)
MT Required
No
MT Device
—
Final mTICI
—

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STEP DOMAIN A (Low NIHSS)
STEP-Domain A (Low NIHSS) — (PI: Demel)
LVO Required
ICA or M1 MCA
LKW
24 hrs
Pre-stroke mRS
0-2
NIHSS
0-5
ASPECTS
>6 (>7 if MRI)
MRI Capability
—
ICT/AC
—
MT Required
—
MT Device
—
Final mTICI
—

ORDER to USE: XXXXXXX
AFTER HOURS CALL: XXXXXXX
ACTIVE SITES: XXXXXXX
Clinicaltrials.gov