Current Stroke Trials
RESEARCH COMMUNICATIONS:
CRC’s will call the 584-UCUC number and page will come across Clinical Communications as: “Research” at [location] – [CRC’s name] requesting. [CB number]
Cheat Sheet for LVO Studies
[For any LVO please contact Yasmin (412-913-8424) and Paul (412-225-5656)
| SISTER (PI: Aziz) | |
|---|---|
| LVO Required | LVO not required Anterior circ perfusion mismatch |
| Pre-stroke mRS | 0-2 |
| NIHSS | ≥4 |
| ASPECTS | ≥6 (≥7 if MRI) |
| MRI Capability | — |
| ICT/AC | No thrombolytics (IV/IA) |
| MT Required | No |
| MT Device | — |
| Final mTICI | — |
| ARPEGGIO (PI: Wechsler) | |
|---|---|
| LVO Required | ICA/M1/M2 |
| Pre-stroke mRS | 0-2 |
| NIHSS | ≥6 |
| ASPECTS | ≥5 |
| MRI Capability | — |
| ICT/AC | No thrombolytics (IV/IA) |
| MT Required | Yes |
| MT Device | Intent to use FDA approved device |
| Final mTICI | 2c-3 |
| STEP-Master (PI: Demel) | |
|---|---|
| LVO Required | Suspected diagnosis AIS Likely causative intracranial LVO or MVO |
| Pre-stroke mRS | — |
| NIHSS | — |
| ASPECTS | — |
| MRI Capability | — |
| ICT/AC | — |
| MT Required | — |
| MT Device | — |
| Final mTICI | — |
| STEP-Domain A (Low NIHSS) (PI: Demel) | |
|---|---|
| LVO Required | ICA or M1 MCA Presentation to enrolling hospital w/in 24h of LKW |
| Pre-stroke mRS | 0-2 |
| NIHSS | 0-5 |
| ASPECTS | >6 (>7 if MRI) |
| MRI Capability | — |
| ICT/AC | — |
| MT Required | — |
| MT Device | — |
| Final mTICI | — |
| ID IMR (PI: Aziz) | |
|---|---|
| LVO Required | ICA/M1/M2 (any) |
| Pre-stroke mRS | — |
| NIHSS | — |
| ASPECTS | — |
| MRI Capability | Must be able to undergo MRI |
| ICT/AC | — |
| MT Required | Yes |
| MT Device | — |
| Final mTICI | 2c-3 |
| TESTED (PI: Demel) | |
|---|---|
| LVO Required | ICA/M1 /M2 (dom) |
| Pre-stroke mRS | 3.4 |
| NIHSS | ≥6 |
| ASPECTS | ≥3 |
| MRI Capability | — |
| ICT/AC | — |
| MT Required | — |
| MT Device | — |
| Final mTICI | — |
| SISTER (PI: Aziz) | STEP-Master (PI: Demel) | STEP-Domain A (Low NIHSS) (PI: Demel) | ARPEGGIO (PI: Wechsler) | ID IMR (PI: Aziz) | TESTED (PI: Demel) | |
|---|---|---|---|---|---|---|
| LVO Required | LVO not required Anterior circ perfusion mismatch | Suspected diagnosis AIS Likely causative intracranial LVO or MVO | ICA or M1 MCA Presentation to enrolling hospital w/in 24h of LKW | ICA/M1/M2 | ICA/M1/M2 (any) | ICA/M1 /M2 (dom) |
| Pre-stroke mRS | 0-2 | — | 0-2 | 0-2 | — | 3.4 |
| NIHSS | ≥4 | — | 0-5 | ≥6 | — | ≥6 |
| ASPECTS | ≥6 (≥7 if MRI) | — | >6 (>7 if MRI) | ≥5 | — | ≥3 |
| MRI Capability | — | — | — | — | Must be able to undergo MRI | — |
| ICT/AC | No thrombolytics (IV/IA) | — | — | No thrombolytics (IV/IA) | — | — |
| MT Required | No | — | — | Yes | Yes | — |
| MT Device | — | — | — | Intent to use FDA approved device | — | — |
| Final mTICI | — | — | — | 2c-3 | 2c-3 | — |
Trial Finder: https://stroke-trial-finder.ajai.dev/f/cincinnati/
