Current Stroke Trials

For SISTER and STEP:  refer to the

Cheat Sheet for ACUTE LVO Studies

For any acute trial questions, contact Yasmin (412-913-8424)

SISTER
(PI: Aziz)		STEP-Domain A
(Low NIHSS)
(PI: Shirani and Demel)		STEP-Domain A
(MVO/DMVO)
(PI: Shirani and Demel)
LVO RequiredLVO not required -
Anterior circ perfusion mismatch		ICA or M1 MCA -
Presents to enrolling
hospital w/in 24h
of LKW		Non-dom/Co-dom M2 or M3 -
Presents to enrolling
hospital w/in 24h
of LKW
Pre-stroke mRS0-20-20-2
NIHSS≥40-5≥8
ASPECTS≥6 (≥7 if MRI)≥6 (≥7 if MRI)≥6 (≥7 if MRI)
MRI Capability———
IV lytcis/AnticoagulantsNo thrombolytics (IV/IA)——
Thrombectomy RequiredNo——
Thrombectomy Device———
Final mTICI———
SISTER
(PI: Aziz)
LVO RequiredLVO not required -
Anterior circ perfusion mismatch
Pre-stroke mRS0-2
NIHSS≥4
ASPECTS≥6 (≥7 if MRI)
MRI Capability—
IV lytcis/AnticoagulantsNo thrombolytics (IV/IA)
Thrombectomy RequiredNo
Thrombectomy Device—
Final mTICI—
ID IMR
(PI: Aziz)
LVO RequiredICA/M1/M2 (any)
Pre-stroke mRS—
NIHSS—
ASPECTS—
MRI CapabilityMust be able to
undergo MRI
IV lytcis/Anticoagulants—
Thrombectomy RequiredYes
Thrombectomy Device—
Final mTICI2c-3
STEP-Domain A
(Low NIHSS)
(PI: Shirani and Demel)
LVO RequiredICA or M1 MCA -
Presents to enrolling
hospital w/in 24h
of LKW
Pre-stroke mRS0-2
NIHSS0-5
ASPECTS≥6 (≥7 if MRI)
MRI Capability—
IV lytcis/Anticoagulants—
Thrombectomy Required—
Thrombectomy Device—
Final mTICI—
STEP-Domain A
(MVO/DMVO)
(PI: Shirani and Demel)
LVO RequiredNon-dom/Co-dom M2 or M3 -
Presents to enrolling
hospital w/in 24h
of LKW
Pre-stroke mRS0-2
NIHSS≥8
ASPECTS≥6 (≥7 if MRI)
MRI Capability—
IV lytcis/Anticoagulants—
Thrombectomy Required—
Thrombectomy Device—
Final mTICI—