| SUBACUTE Trial criteria One-Liners | ASPIRE | Apixaban to treat nonvalvular Afib post ICH |
| CAPTIVA | Comparing Ticagrelor/ASA, Rivaroxaban/ASA VS Clopidogrelet for Severe ICAD with downstream stroke. |
| DISCOVERY | Mechanisms of post-stroke cognitive impairment and dementia |
| LIBREXIA | Factor Xia inhibitor in addition to SOC meds for AIS or TIA |
| PSR | Postural stability for walking and balance recovery |
| SATURN | Satin vs. no statin for pts with spontenous hemorrage |
| SleepSMART | OSA in acute stroke and use of CPAP for treatment |
| TESTED | LVO with prestroke disability (mRS 3-4) comparing EVT to MM |
| VERIFY | TMS biomarker study for patients with UE weakness |
ASPIRE
Apixaban vs ASA to treat nonvalvular Afib post ICH
ASPIRE— (PI: Stanton)
Coordinators:
Jennifer Powers: 513-482-0617
Population:
ICH
Stroke locataion:
All ICH
Last Known Normal:
180 days
NIHSS:
—
mRS
—
Other I/E:
Afib diagnosis and on AC
Sites:
UCMC
ORDERS:
Baseline blood draw
CAPTIVA
Comparing Ticagrelor/ASA, Rivaroxaban/ASA VS Clopidogrelet for Severe ICAD with downstream stroke.
CAPTIVA— (PI: Aziz)
Coordinator:
Marchele Nowell-Bostic: 513-328-1606
Population:
AIS
Stroke locataion:
70-99% intracranial stenosis
Last Known Normal:
30 days
NIHSS:
—
mRS
—
Other I/E:
must self conset, ages 30-80, no substance abuse, no AC
Sites:
UCMC
DISCOVERY
Investigating mechanisms of post-stroke cognitive impairment and dementia
DISCOVERY — (PI: Demel)
Coordinators:
Population:
AIS, non-traumatic ICH, or aSAH
Stroke locataion:
n/a
Last Known Normal:
6 weeks
NIHSS:
—
mRS
—
Other I/E:
no cognitive impairment
ORDERS:
Baseline blood draw
Sites:
UCMC, WCH
LIBREXIA
Facor Xia in addition to SOC meds for AIS and TIA
LIBREXIA — (PI: Flaherty)
Coordinator:
Marchele Nowell-Bostic: 513-328-1606
Population:
AIS or TIA
Stroke locataion:
—
Last Known Normal:
48 h
NIHSS:
≤ 7
mRS
0-2
TIA ABCD2
≥ 6
Other I/E:
Age >40, no AC
ORDERS:
aPTT if they get lytics and then a blood draw for pre randomization labs
Sites:
UCMC
PSR
Postural stability for walking and balance recovery
PSR — (PI: Awisoka)
Coordinator:
Colin Drury: 513-558-7656
Population:
AIS
Stroke locataion:
unilateral stroke
Last Known Normal:
2 weeks
NIHSS:
—
mRS
—
Other I/E:
no LE weakness, must self consent
Sites:
UCMC
SATURN
Statin vs. no statin for pts with spontenous hemmorhage
SATURN — (PI: Stanton)
Coordinators:
Jennifer Powers: 513-482-0617
Population:
ICH
Stroke locataion:
lobar; non-traumatic
Last Known Normal:
7 days
NIHSS:
—
mRS
—
Other I/E:
on statin before onset, age <50
ORDERS:
Baseline blood draw
Sites:
UCMC
SleepSMART
OSA in acute stroke and use of CPAP for treatment
SleepSMART — (PI: Kreitzer)
Coordinators:
Population:
AIS
Stroke locataion:
n/a
Last Known Normal:
7 days
NIHSS:
≥ 1
mRS
—
Other I/E:
Vo current CPAP use
Sites:
UCMC, WCH, Christ
TESTED
LVO with prestroke disability (mRS 3-4) comparing EVT to MM
TESTED — (PI: DEMEL)
Coordinators:
Jennifer Powers: 513-482-0617
Population:
AIS
Stroke locataion:
LVO - ICA, M1, dominant M2
Last Known Normal:
24hrs (enrollment up to 5 days)
NIHSS:
≥ 6
mRS
3-4
Other I/E:
EVT or no-EVT qualifies
Sites:
UCMC, Jewish
VERIFY
TMS biomarker study for patients with UE weakness
VERIFY — (PI: Awosika)
Coordinator:
Colin Drury: 513-558-7656
Population:
AIS
Stroke locataion:
Unilateral stroke
Last Known Normal:
48-96 h
NIHSS:
—
mRS
—
Other I/E:
UE weakness, must self-consent
ORDERS:
Research MRI if an MRI has not been completed
Sites:
UCMC