SUBACUTE Trial criteria One-Liners
ASPIRE Apixaban to treat nonvalvular Afib post ICH
CAPTIVA Comparing Ticagrelor/ASA, Rivaroxaban/ASA VS Clopidogrelet for Severe ICAD with downstream stroke.
DISCOVERY Mechanisms of post-stroke cognitive impairment and dementia
LIBREXIA Factor Xia inhibitor in addition to SOC meds for AIS or TIA
PSR Postural stability for walking and balance recovery
SATURN Satin vs. no statin for pts with spontenous hemorrage
SleepSMART OSA in acute stroke and use of CPAP for treatment
TESTED LVO with prestroke disability (mRS 3-4) comparing EVT to MM
VERIFY TMS biomarker study for patients with UE weakness
ASPIRE

Apixaban vs ASA to treat nonvalvular Afib post ICH

ASPIRE— (PI: Stanton)
Coordinators:
Jennifer Powers: 513-482-0617
Population:
ICH
Stroke locataion:
All ICH
Last Known Normal:
180 days
NIHSS:
mRS
Other I/E:
Afib diagnosis and on AC
Sites:
UCMC
ORDERS:
Baseline blood draw

CAPTIVA

Comparing Ticagrelor/ASA, Rivaroxaban/ASA VS Clopidogrelet for Severe ICAD with downstream stroke.

CAPTIVA— (PI: Aziz)
Coordinator:
Marchele Nowell-Bostic: 513-328-1606
Population:
AIS
Stroke locataion:
70-99% intracranial stenosis
Last Known Normal:
30 days
NIHSS:
mRS
Other I/E:
must self conset, ages 30-80, no substance abuse, no AC
Sites:
UCMC

DISCOVERY

Investigating mechanisms of post-stroke cognitive impairment and dementia

DISCOVERY — (PI: Demel)
Coordinators:
Marchele Nowell-Bostic: 513-328-1606
Jennifer Powers: 513-482-0617
Ranjaka Gunawardena: 513-884-3260
Population:
AIS, non-traumatic ICH, or aSAH
Stroke locataion:
n/a
Last Known Normal:
6 weeks
NIHSS:
mRS
Other I/E:
no cognitive impairment
ORDERS:
Baseline blood draw
Sites:
UCMC, WCH

LIBREXIA

Facor Xia in addition to SOC meds for AIS and TIA

LIBREXIA — (PI: Flaherty)
Coordinator:
Marchele Nowell-Bostic: 513-328-1606
Population:
AIS or TIA
Stroke locataion:
Last Known Normal:
48 h
NIHSS:
≤ 7
mRS
0-2
TIA ABCD2
≥ 6
Other I/E:
Age >40, no AC
ORDERS:
aPTT if they get lytics and then a blood draw for pre randomization labs
Sites:
UCMC

PSR

Postural stability for walking and balance recovery

PSR — (PI: Awisoka)
Coordinator:
Colin Drury: 513-558-7656
Population:
AIS
Stroke locataion:
unilateral stroke
Last Known Normal:
2 weeks
NIHSS:
mRS
Other I/E:
no LE weakness, must self consent
Sites:
UCMC

SATURN

Statin vs. no statin for pts with spontenous hemmorhage

SATURN — (PI: Stanton)
Coordinators:
Jennifer Powers: 513-482-0617
Population:
ICH
Stroke locataion:
lobar; non-traumatic
Last Known Normal:
7 days
NIHSS:
mRS
Other I/E:
on statin before onset, age <50
ORDERS:
Baseline blood draw
Sites:
UCMC

SleepSMART

OSA in acute stroke and use of CPAP for treatment

SleepSMART — (PI: Kreitzer)
Coordinators:
Ranjaka Gunawardena: 513-884-3260
Jennifer Powers: 513-482-0617
Population:
AIS
Stroke locataion:
n/a
Last Known Normal:
7 days
NIHSS:
≥ 1
mRS
Other I/E:
Vo current CPAP use
Sites:
UCMC, WCH, Christ

TESTED

LVO with prestroke disability (mRS 3-4) comparing EVT to MM

TESTED — (PI: DEMEL)
Coordinators:
Jennifer Powers: 513-482-0617
Population:
AIS
Stroke locataion:
LVO - ICA, M1, dominant M2
Last Known Normal:
24hrs (enrollment up to 5 days)
NIHSS:
≥ 6
mRS
3-4
Other I/E:
EVT or no-EVT qualifies
Sites:
UCMC, Jewish

VERIFY

TMS biomarker study for patients with UE weakness

VERIFY — (PI: Awosika)
Coordinator:
Colin Drury: 513-558-7656
Population:
AIS
Stroke locataion:
Unilateral stroke
Last Known Normal:
48-96 h
NIHSS:
mRS
Other I/E:
UE weakness, must self-consent
ORDERS:
Research MRI if an MRI has not been completed
Sites:
UCMC